Monday, November 15, 2010

Mobile Home Ceiling Paneling

Cold baby goodbye. Spray the defeat


The result obtained by the scholars of Cambridge, the English laboratory Nobel. "Antibodies ambush inside the cell." The mechanism will also be useful in combating many other more dangerous viruses, such as those that cause gastroenteritis


Goodbye stuffy nose, burning throat, coughing and sneezing. Scientists at Cambridge University have discovered the cure for a cold to disappear. The most common disease in the world, affecting every year, several times a year, millions of people of all ages, will be defeated.

may be eradicated thanks to the antibodies in our immune system and a protein that attaches to the virus destroying it. Should be ready within a decade, a medicine, probably a spray can get rid of the nuisance which articulates the autumns, winters and sometimes the other seasons. For the pharmaceutical industry the result is a goldmine of new revenues. For authors of discovery sees the possibility of the Nobel Prize. And for all the suffering in the cold is approaching the end of runny nose and sneezing in the series.

The breakthrough is the result of exceptional scholars in a town famous all over the planet: the Laboratory of Molecular Biology, University of Cambridge, dubbed the "factory Nobel "for the number of prizes won (14). You become 15 when l'impatto di questa nuova scoperta comincerà a farsi sentire. Merito di una piccola squadra di giovani studiosi, guidati dal dottor Leo James. Un team di cui fa parte anche un ricercatore 26enne, William McEwan, con un cognome ben noto: suo padre è Ian McEwan, uno degli scrittori più affermati del Regno Unito, autore di romanzi diventati best-seller in tutto il globo. "Sono enormemente orgoglioso e felice per mio figlio", dice a "Repubblica" il romanziere. "Era innamorato della scienza fin da piccolo, a tre anni andava a letto con un atlante o un enciclopedia". Il Nobel, nella famiglia McEwan, potrebbe vincerlo prima il figlio del padre, per la biologia anziché per la letteratura.

The novelty of the discovery made by British scientists is this: for the first time have found that the immune system of the human body can destroy the cold virus "after" that has invaded the interior of a human cell, an undertaking until now considered impossible. Dr. James and his colleagues have demonstrated that antibodies of the immune system can enter the cell with the virus invader and there, inside the cell itself, manage to destroy it very quickly. "It's like an ambush that antibodies tend to the virus," Dr. James writes in the journal Proceedings of the National Academy of Sciences. "Once the immune mechanism comes into operation, the virus is eliminated in the space of an hour or two. It is a fast process."

A staff member who makes out the cold is a protein called Trim 21, located in the cells. Working on this protein, in the future should be possible to produce a nasal spray that can eradicate the common cold. But not only. The same discovery, the idea that antibodies can destroy a virus anche dopo il suo ingresso nelle cellule umane, potrebbe eliminarne molti altri, da quello che provoca il vomito a quello che causa diarrea e gastroenterite: virus che uccidono migliaia di bambini ogni anno nei paesi in via di sviluppo. In tal senso, il valore della scoperta fatta a Cambridge è storico. I virus sono i peggiori killer dell'umanità: fanno il doppio delle vittime dei tumori. Avere trovato il modo di metterli fuori uso è una pietra miliare per la medicina. Non a caso è successo nella "fabbrica dei Nobel", lo stesso laboratorio in cui nel 1953 Jim Watson e Francis Crick scoprirono i segreti del Dna. La notizia era ieri sulle prima pagine di tutti i giornali inglesi. È al dottor James, al figlio di McEwan e ai loro colleghi che dovremo dire grazie, se entro dieci anni non ci lamenteremo più del raffreddore.

FONTE: Enrico Franceschini (repubblica.it)

Sunday, November 14, 2010

How To Regain Kidney Function

AIDS vaccine Italian regenerates the immune system


Il vaccino terapeutico italiano anti-Aids, in fase di sperimentazione, riporta verso la normalità le funzioni immunitarie dei malati. Un risultato più che promettente, “entusiasmante” lo definisce Barbara Ensoli, del Centro nazionale AIDS dell’Istituto superiore di Sanità, che sta sviluppando il vaccino.

Uno studio pubblicato magazine PlosOne , which reports the results of the interim analysis of phase II clinical trial, shows that in 87 patients after 48 weeks significantly improves the immune system already compromised by the virus, thanks to the combined vaccine Tat with antiretroviral therapy.

'improve their quality of life - says Ensoli - because even if the treatment stops the virus fail to block a range of other disorders that continue to be, from cardiovascular to those in the brain, up to premature aging, with people 40 years shows that 70. " A perverse effect of Tat, the real "engine" of the HIV virus, which continues to act even while receiving antiretroviral therapy and compromise the immune system. Just Tat acts against the vaccine, triggering an immune response lasting, ultimately making the virus a car without engine, and defuse the destructive action.

"This vaccine - says Ensoli - get where drugs do not arrive. Block immunoattivazione, increased B cells, immune cells gather capabilities, there is in fact a return to equilibrium in patients already receiving an effective drug therapy. "

"These results - highlights the ISS President Enrico Garaci - dimostrano che valeva la pena di esplorare le potenzialità del vaccino Tat. Il miglioramento dei parametri immunologici nei pazienti vaccinati trattati con terapia antiretrovirale rappresenta una tappa importante, e non ci fermiamo qui». I passi successivi sono ancora più ambiziosi: valutare l’effetto del vaccino in pazienti sintomatici, per bloccare la malattia, e poi valutare l’effetto preventivo del vaccino, ossia su pazienti sani. «Il meccanismo della Tat è sempre quello - conferma Ensoli - e noi speriamo che il vaccino funzioni anche per le altre indicazioni. Finora abbiamo ottenuto risultati superiori alle nostre aspettative, e molto rapidi».

L’iter di sperimentazione del vaccino Italian treatment started 15 years ago, the clinical phase I started in 2003, Phase II in 2008 and has yet to finish. The problem, however, said Ensoli, time is money: "We no longer have funds to complete Phase II."

beginning of the trial were spent around 20 million euro, against the Ministry of Health and Iss, "but the figure was 20 times higher," highlights Garaci, to test whether the vaccine had been an private rather than public bodies. Now the ISS holds 10 patents which, when it comes to produce the vaccine will also be sold to private companies. "Our goal is to treat patients and we have no foreclosure on transparent partnerships with the private sector, "concludes Ensoli.

SOURCE lastampa.it

Wednesday, November 10, 2010

Skate Sharpining Machines For Sale

American Scientists obtained from blood cells Skin


produce human blood stem cells from skin, blood, of course, identical to the patient. It could be a revolutionary breakthrough for blood transfusions the discovery by scientists at McMaster University in Hamilton, Ontario, who have discovered how to make human blood from adult human skin.

The discovery, published in the prestigious scientific journal Nature , it could mean that in future patients in need of blood (during surgery, cancer treatment, a transplant or many other applications) may be transfused blood consists of cells with their own DNA.

times? According to scientists, human clinical trials could start in 2012. Mick Bhatia, scientific director of McMaster's Stem Cell and Cancer Research Institute at the G. Michael Degroote School of Medicine, and his team of researchers have also shown that the "conversion" from skin cells to blood cells is direct, does not require the intermediate step of transforming the stem cells of the skin and then turn them into pluripotent stem cells in the blood.

"We have shown that this works with the human skin. We know how it works and I think it can also improve the process, "said Bhatia. "We are at work - he added - to derive stem cells from other types of skin."

The discovery has been replicated many times over two years with human skin is that fewer young people by young people to show that it works for any age. The researchers took samples of skin and then extracted stem cells grown in the laboratory. He was then just add to stem a transcription factor, which is a protein that induces genes to "turn on" to reprogram cells directly and transform into blood cells.

SOURCE: lastampa.it