Stress plays a role not only in the arrival of white hair, but also the loss of hair. A common problem, so that over the years have multiplied and lotions miraculous drug treatments against baldness. But also effective products are unable to return a luxuriant head of hair. Now a team led by researchers at the University of California at Los Angeles (USA) and the Veterans Administration, thinks he has found a solution.
The discovery came by accident . Investigating how stress effect on gastrointestinal function, U.S. researchers think they have found a chemical compound that induces hair growth by blocking the stress hormone. The unexpected discovery is described online at "PLoS One". "Our results demonstrate that a short-term treatment with this compound causes an incredible long-term hair growth in mutant mice, chronically stressed," says Mulugeta Million, the David Geffen School of Medicine at UCLA. "This could open new ways to treat hair loss in humans through the modulation of stress hormone receptors, in particular against hair loss related to chronic stress and aging."
SOURCE: ilmesaggero.it
The research team, who originally studied the brain-gut interactions,
Researchers at the Salk had developed the chemical compound, a peptide called astressin-B , describing its ability to block the action of CRF. Thus were created the animals engineered for that purpose. Bald mice by injecting the molecule, the researchers at UCLA have found that a single application showed no effects, so they continued for five days, to give the peptide a better chance to block the receptors' in the viewfinder. They then observed the effects in the colon of animals subjected to stress led, putting them in cages along with the hairy mice used to make the comparison.
About three months later, investigators retrieved out mice to be more research into gastrointestinal and found it could no longer distinguish the genetically modified animals from normal. The hair had grown back, thick and glossy, glabrous on the backs above. "When we analyzed the identification number of the mice on which the hair was' back we discovered that, in fact, the peptide was responsible for the super-bald regrowth in mice," says Mulugeta. "Subsequent studies have confirmed this phenomenon in an unequivocal manner."
Of particular interest, according to the authors, is the short duration of treatment: only one injection a day for five consecutive days is sufficient to maintain the effects for up to four months. "A relatively long time, since the mice live less than two years," added Mulugeta. If the effect is preserved in humans, the peptide could provide a lasting solution to the nightmare baldness. UCLA and the Salk Institute believe in it, so who applied for a patent for the use of peptide astressin-B for the growth of hair. also includes researchers at the Salk Institute for Biological Studies in La Jolla, California, and Oregon Health Sciences University. For their experiments, the researchers used mice genetically engineered to overproduce a stress hormone: the corticotropin-releasing factor (CRF). These mice lose hair with age and eventually become bald on his back, which makes them very recognizable.
SOURCE: ilmessaggero.it
The discovery came by accident . Investigating how stress effect on gastrointestinal function, U.S. researchers think they have found a chemical compound that induces hair growth by blocking the stress hormone. The unexpected discovery is described online at "PLoS One". "Our results demonstrate that a short-term treatment with this compound causes an incredible long-term hair growth in mutant mice, chronically stressed," says Mulugeta Million, the David Geffen School of Medicine at UCLA. "This could open new ways to treat hair loss in humans through the modulation of stress hormone receptors, in particular against hair loss related to chronic stress and aging."
SOURCE: ilmesaggero.it
The research team, who originally studied the brain-gut interactions,
Researchers at the Salk had developed the chemical compound, a peptide called astressin-B , describing its ability to block the action of CRF. Thus were created the animals engineered for that purpose. Bald mice by injecting the molecule, the researchers at UCLA have found that a single application showed no effects, so they continued for five days, to give the peptide a better chance to block the receptors' in the viewfinder. They then observed the effects in the colon of animals subjected to stress led, putting them in cages along with the hairy mice used to make the comparison.
About three months later, investigators retrieved out mice to be more research into gastrointestinal and found it could no longer distinguish the genetically modified animals from normal. The hair had grown back, thick and glossy, glabrous on the backs above. "When we analyzed the identification number of the mice on which the hair was' back we discovered that, in fact, the peptide was responsible for the super-bald regrowth in mice," says Mulugeta. "Subsequent studies have confirmed this phenomenon in an unequivocal manner."
Of particular interest, according to the authors, is the short duration of treatment: only one injection a day for five consecutive days is sufficient to maintain the effects for up to four months. "A relatively long time, since the mice live less than two years," added Mulugeta. If the effect is preserved in humans, the peptide could provide a lasting solution to the nightmare baldness. UCLA and the Salk Institute believe in it, so who applied for a patent for the use of peptide astressin-B for the growth of hair. also includes researchers at the Salk Institute for Biological Studies in La Jolla, California, and Oregon Health Sciences University. For their experiments, the researchers used mice genetically engineered to overproduce a stress hormone: the corticotropin-releasing factor (CRF). These mice lose hair with age and eventually become bald on his back, which makes them very recognizable.
SOURCE: ilmessaggero.it
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